Module #1: Risks and Prevention

Module #1: Risks and Prevention >> Introduction to Breast Cancer

More developed countries have a lower incidence of breast cancer, a lower mortality rate than less developed countries

More developed countries have a higher incidence of breast cancer, and a higher mortality rate than less developed countries

More developed countries have a lower incidence of breast cancer, and a higher mortality rate than less developed countries

More developed countries have a higher incidence of breast cancer, a lower mortality rate than less developed countries

Being a woman and getting older

Being exposed to estrogen and getting older

Being a woman and having a family history or genetic predisposition

Having a family history or genetic predisposition and being exposed to estrogen

Breast feeding

Getting a mammogram

Reducing alcohol use

Maintaining an ideal body weight

5-10%

15-20%

45-50%

80-85%

Men who have breast cancer should be tested for BRCA 2

If you have a mutation, you are guaranteed to get breast and/or ovarian cancer

Mutation carriers have a higher risk of prostate and pancreatic cancer

It is transmitted in an autosomal dominant fashion

A 73 year old Ashkenazi Jewish lady who has a small breast cancer found on screening mammogram

A 43 year old who presents with breast cancer, but no one in her family has the disease

A 67 year old who has a triple negative breast cancer that presented with a mass

A 57 year old lady who has ovarian cancer

Li-Fraumeni: p53

Cowden: PTEN

Hereditary diffuse gastric cancer: CDH1

Peutz-Jeghers: E-cadherin

This refers to taking chemotherapy to prevent breast cancer

It reduces your risk of developing breast cancer by 50%

It is the most effective way to reduce one’s risk of getting breast cancer

It works by turning off your ovarian production of estrogen

Having a 5-year risk of developing breast cancer of 1.67 or greater by Gail model

Having a family history of a BRCA 1 or 2 gene mutation

Having a BRCA 1 or 2 gene mutation

Having a 20-25% lifetime risk of developing breast cancer by BRCAPRO model

Cataracts

Endometrial cancer

Fractures

Blood clots

Bilateral prophylactic oophorectomy

Bilateral prophylactic mastectomy

Chemoprevention

Getting annual mammograms

Module #1: Risks and Prevention >> Introduction to Breast Cancer